Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9848968 | 0.99 | ALDH1A1 (0.49) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL9129025 | 0.83 | ALDH1A1 (0.45) | ALDH1A1HTTNCOA1SMN1; SMN2NCOA3 | |
| SCHEMBL353339 | 0.82 | EPHX2 (0.44) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL353673 | 0.82 | EPHX2 (0.44) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL9127621 | 0.80 | MTOR (0.55) | ALDH1A1ADRB3MAPTCYP3A4 | |
| SCHEMBL10231532 | 0.79 | CNR1 (0.52) | MAPTKDM4ECYP3A4SIGMAR1 | |
| SCHEMBL10231525 | 0.79 | CNR1 (0.52) | MAPTKDM4ECYP3A4SIGMAR1 | |
| SCHEMBL12905042 | 0.79 | CNR1 (0.52) | MAPTKDM4ECYP3A4SIGMAR1 | |
| SCHEMBL916682 | 0.79 | SIGMAR1 (0.65) | CYP1A2CYP2D6CYP2C19SIGMAR1 | |
| SCHEMBL9848956 | 0.79 | MTOR (0.57) | ALDH1A1ADRB3MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5422355-A | Also for treating memory impairment, dementia or cerebral insufficiency | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-06-06 | — | — | US | disclosed |
| US-5260331-A | Selective gamma aminobutyric acid autoreceptors; treatment of dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| US-5086073-A | Brain disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-04 | — | — | US | disclosed |
| EP-0407032-A2 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-09 | — | — | EP | disclosed |