Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11463734 | 0.88 | MAPT (0.62) | KCNH2MAPTHRH3 | |
| SCHEMBL11871026 | 0.86 | KCNH2 (0.60) | KCNH2MAPT | |
| SCHEMBL9131306 | 0.82 | TMEM97 (0.56) | KCNH2MAPT | |
| SCHEMBL8995945 | 0.82 | MEN1 (0.45) | KCNH2MAPTHRH3 | |
| SCHEMBL8995934 | 0.80 | HTT (0.44) | KCNH2MAPT | |
| SCHEMBL16421915 | 0.79 | MAPT (0.71) | MAPTHRH3 | |
| SCHEMBL172516 | 0.79 | MAPT (0.60) | KCNH2MAPT | |
| SCHEMBL7130261 | 0.79 | MAPT (0.70) | KCNH2MAPTHRH3 | |
| SCHEMBL11366830 | 0.79 | HRH3 (0.67) | KCNH2HRH3 | |
| SCHEMBL8987727 | 0.78 | KCNH2 (0.44) | KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0407032-B1 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | WYETH JOHN & BROTHER LTD (GB) | 1994-11-09 | — | — | EP | claimed |
| US-5086073-A | Brain disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-04 | — | — | US | claimed |
| EP-0407032-A2 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-09 | — | — | EP | claimed |
| US-5422355-A | Also for treating memory impairment, dementia or cerebral insufficiency | JOHN WYETH & BROTHER, LIMITED (GB) | 1995-06-06 | — | — | US | disclosed |
| EP-0407032-B1 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | WYETH JOHN & BROTHER LTD (GB) | 1994-11-09 | — | — | EP | disclosed |
| US-5260331-A | Selective gamma aminobutyric acid autoreceptors; treatment of dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| US-5086073-A | Brain disorders | JOHN WYETH & BROTHER LIMITED (GB) | 1992-02-04 | — | — | US | disclosed |
| EP-0407032-A2 | Aromatic and heteroaromatic amines for treating depressions, cerebral insufficiency disorders or dementia | JOHN WYETH & BROTHER LIMITED (GB) | 1991-01-09 | — | — | EP | disclosed |