Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987727 | 0.94 | KCNH2 (0.44) | HTTDPP7KCNH2L3MBTL1ALDH1A1 | |
| SCHEMBL8709076 | 0.86 | GBA1 (0.41) | HTTKCNH2SIGMAR1MAPT | |
| SCHEMBL6268004 | 0.83 | HTT (0.50) | HTTDPP7ALDH1A1RAB9AMAPT | |
| SCHEMBL8995945 | 0.82 | MEN1 (0.45) | HTTDPP7KCNH2ALDH1A1RAB9A | |
| SCHEMBL9129256 | 0.80 | KCNH2 (0.62) | KCNH2MAPT | |
| SCHEMBL140525 | 0.79 | HDAC3 (0.54) | HTTKCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL9129725 | 0.78 | TAAR1 (0.47) | DPP7KCNH2MAPTAOC3 | |
| SCHEMBL8987696 | 0.78 | HDAC3 (0.46) | HTTDPP7ALDH1A1RAB9ATMEM97 | |
| SCHEMBL8987627 | 0.78 | CYP2C9 (0.47) | HTTDPP7ALDH1A1RAB9ATMEM97 | |
| SCHEMBL8995931 | 0.77 | FDPS (0.43) | HTTDPP7KCNH2ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | disclosed |