Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6268546 | 0.85 | ALDH1A1 (0.49) | MEN1KMT2AMAPTALDH1A1HTT | |
| SCHEMBL8995934 | 0.82 | HTT (0.44) | MEN1KMT2AMAPTKCNH2ALDH1A1 | |
| SCHEMBL9129256 | 0.82 | KCNH2 (0.62) | MAPTKCNH2HRH3 | |
| SCHEMBL6947716 | 0.81 | HDAC3 (0.50) | MEN1KMT2AKCNH2ALDH1A1HTT | |
| SCHEMBL9129725 | 0.80 | TAAR1 (0.47) | MAPTKCNH2DPP7AOC3 | |
| SCHEMBL8987727 | 0.80 | KCNH2 (0.44) | MAPTKCNH2ALDH1A1HTTRAB9A | |
| Hydrochloric Acid SCHEMBL1593455 | 0.79 | HDAC3 (0.49) | MEN1KMT2AKCNH2ALDH1A1HRH3 | |
| SCHEMBL9704934 | 0.78 | BCHE (0.47) | MEN1KMT2AMAPTKCNH2ALDH1A1 | |
| SCHEMBL8987611 | 0.77 | NPC1 (0.42) | MAPTKCNH2ALDH1A1HRH3DPP7 | |
| SCHEMBL6268004 | 0.77 | HTT (0.50) | MEN1KMT2AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538956-A | G-AMINOBUTYRIC ACID AUTORECEPTOR AGONISTS, ANTIDEPRESSANTS, TREATING SENILE DEMENTIA | JOHN WYETH & BROTHER, LIMITED (GB) | 1996-07-23 | — | — | US | disclosed |
| WO-1993011138-A1 | AMINE DERIVATIVES CONTAINING A PHOSPHONIC, PHOSPHONOUS OR PHOSPHINIC ACID MOIETY | JOHN WYETH & BROTHER LIMITED (GB) | 1993-06-10 | — | — | WO | disclosed |