Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132668 | 0.87 | KDM4E (0.40) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL5572235 | 0.84 | GAA (0.50) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8542113 | 0.80 | KDM4E (0.55) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8542090 | 0.77 | KMT2A (0.52) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL27317680 | 0.77 | TPMT (0.55) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8542054 | 0.74 | GAA (0.42) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL262782 | 0.73 | SMN1; SMN2 (0.43) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8542183 | 0.73 | SMN1; SMN2 (0.45) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL8542186 | 0.73 | SMN1; SMN2 (0.45) | KDM4EGAATSHRSMN1; SMN2NPC1 | |
| SCHEMBL9130003 | 0.72 | TPMT (0.60) | KDM4EGAASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5447925-A | Carbapenems with side-chain S; use to treat infections | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-09-05 | — | — | US | disclosed |
| EP-0580632-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |
| WO-1992017480-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |