Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | LIG1 | P18858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11226244 | 0.87 | KDM4E (0.55) | KDM4ETSHRGAAPDE4BLIG1 | |
| SCHEMBL15312851 | 0.85 | KDM4E (0.60) | KDM4ETSHRGAAPDE4BALDH1A1 | |
| SCHEMBL22229873 | 0.83 | KDM4E (0.62) | KDM4ETSHRGAAPDE4BLIG1 | |
| SCHEMBL13690626 | 0.82 | KDM4E (0.57) | KDM4ETSHRGAAPDE4BLIG1 | |
| SCHEMBL19815469 | 0.81 | KDM4E (0.46) | KDM4ETSHRGAAPDE4BLIG1 | |
| SCHEMBL4331415 | 0.80 | KDM4E (0.55) | KDM4ETSHRGAAPDE4BLIG1 | |
| SCHEMBL4363165 | 0.77 | KMT2A (0.43) | TSHRALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL711175 | 0.77 | NPC1 (0.54) | KDM4EALDH1A1HPGDMAPTNPC1 | |
| SCHEMBL184107 | 0.77 | TSHR (0.60) | KDM4ETSHRALDH1A1HPGDLMNA | |
| SCHEMBL8484361 | 0.76 | KDM4E (0.66) | KDM4ETSHRGAAPDE4BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2290839-A | — | — | None | — | — | JP | disclosed |
| US-5447925-A | Carbapenems with side-chain S; use to treat infections | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-09-05 | — | — | US | disclosed |
| EP-0580632-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LIMITED (GB) | 1994-02-02 | — | — | EP | disclosed |
| WO-1992017480-A1 | ANTIBIOTIC CARBAPENEM DERIVATIVES | ZENECA LTD. (GB) | 1992-10-15 | — | — | WO | disclosed |
| JP-H02290839-A | ESTER DERIVATIVE | MITSUBISHI KASEI CORP | 1990-11-30 | — | — | JP | disclosed |