Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RHOA | P61586 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ATIC | P31939 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11621161 | 0.81 | ALDH1A1 (0.58) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL28012650 | 0.80 | GAA (0.57) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL26677370 | 0.77 | NPC1 (0.59) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL9828989 | 0.75 | KDM4E (0.61) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL28314061 | 0.74 | PDGFRB (0.56) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL27340469 | 0.74 | PDGFRB (0.56) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL8515227 | 0.74 | KDM4E (0.70) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL28682772 | 0.73 | KDM4E (0.64) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A | |
| SCHEMBL9132010 | 0.73 | KDR (0.61) | KDM4ENPC1RAB9AALDH1A1HSD17B10 | |
| SCHEMBL29186499 | 0.72 | KDM4E (0.68) | KDM4EHSP90AA1HSP90AB1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | claimed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |