Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL651159 | 0.83 | KDR (0.74) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27777663 | 0.83 | KDR (0.53) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27866684 | 0.78 | NPC1 (0.80) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL23880568 | 0.77 | KDR (0.70) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL31306411 | 0.77 | BCAT1 (0.64) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL995474 | 0.76 | KDR (1.00) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL7836629 | 0.76 | KDR (0.60) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL879571 | 0.75 | KDM4E (0.70) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL27617535 | 0.75 | KDR (0.68) | KDRRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL3994400 | 0.75 | NPSR1 (0.71) | KDRRAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | claimed |
| CN-103958509-B | 6-substituted 3- (quinolin-6-ylthio) - [1,2,4] triazolo [4,3-a ] pyridine compounds as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2015-12-23 | — | — | CN | disclosed |
| CN-103958509-A | 6-substituted 3- (quinolin-6-ylthio) - [1,2,4] triazolo [4,3-a ] pyridine compounds as tyrosine kinase inhibitors | NOVARTIS AG | 2014-07-30 | — | — | CN | disclosed |
| CN-101535303-B | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | NOVARTIS AG | 2012-07-18 | — | — | CN | disclosed |
| CN-101535303-A | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | NOVARTIS AG (CH) | 2009-09-16 | — | — | CN | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |