Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 9/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL9131218 | 0.95 | ADRB2 (0.51) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9131862 | 0.93 | ADRB2 (0.53) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9132856 | 0.92 | ADRB3 (0.48) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9132659 | 0.92 | HTR1A (0.49) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9131595 | 0.91 | ADRB3 (0.48) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9131158 | 0.90 | ADRB3 (0.47) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9132463 | 0.89 | HTR1A (0.44) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9135861 | 0.88 | ADRB3 (0.51) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9129242 | 0.88 | ADRB3 (0.50) | ADRB2ADRB3ADRB1CYP1A2MEN1 | |
| SCHEMBL9133110 | 0.88 | HTR1A (0.69) | ADRB2ADRB3ADRB1CYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0275762-B1 | Indole carboxamide derivatives and their salts, process and intermediates for their preparation, their use as medicines and compositions containing them | ROUSSEL UCLAF (FR) | 1993-11-18 | — | — | EP | claimed |
| US-5084455-A | Antiarrhythmia agents for mammals | ROUSSEL UCLAF (FR) | 1992-01-28 | — | — | US | claimed |
| EP-0213984-B1 | INDOLE CARBOXAMIDE DERIVATIVES, THEIR SALTS, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICINES AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1991-01-09 | — | — | EP | claimed |
| US-4791109-A | Novel indole carboxamides | ROUSSEL UCLAF (FR) | 1988-12-13 | — | — | US | claimed |
| US-5380722-A | Antiarrhythmia agents | ROUSSEL-UCLAF (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5084455-A | Antiarrhythmia agents for mammals | ROUSSEL UCLAF (FR) | 1992-01-28 | — | — | US | disclosed |
| US-4908367-A | Antiarrythmic agents | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| US-4791109-A | Novel indole carboxamides | ROUSSEL UCLAF (FR) | 1988-12-13 | — | — | US | disclosed |