Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | HTR2A | P28223 | 8/20 | 0.53 |
| ▸ | HTR7 | P34969 | 8/20 | 0.53 |
| ▸ | HTR6 | P50406 | 8/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | DRD3 | P35462 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9132047 | 0.90 | HTR1A (0.42) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9130014 | 0.85 | DRD2 (0.59) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9134856 | 0.85 | DRD2 (0.60) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132082 | 0.84 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9134836 | 0.81 | DRD2 (0.52) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9130339 | 0.80 | HTR1A (0.57) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9134847 | 0.80 | DRD2 (0.48) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9132141 | 0.80 | DRD2 (0.53) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9131992 | 0.80 | HTR1A (0.51) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9130462 | 0.80 | DRD2 (0.50) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5453437-A | 1,3-disubstituted pyrrolidines | BAYER AKTIENGESELLSCHAFT (DE) | 1995-09-26 | — | — | US | disclosed |
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |
| EP-0338331-B1 | 1,3 DISUBSTITUTED PYRROLIDINES | BAYER AG (DE) | 1992-10-21 | — | — | EP | disclosed |
| US-5037841-A | For treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1991-08-06 | — | — | US | disclosed |
| EP-0338331-A1 | 1,3 Disubstituted Pyrrolidines | BAYER AG (DE) | 1989-10-25 | — | — | EP | disclosed |