Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.67 |
| ▸ | RARG | P13631 | 6/20 | 0.67 |
| ▸ | RARA | P10276 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | PGR | P06401 | 1/20 | 0.67 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.67 |
| ▸ | GOT1 | P17174 | 1/20 | 0.67 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | HPSE | Q9Y251 | 8/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | ALB | P02768 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460028 | 0.87 | RARB (0.50) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL8458032 | 0.83 | RARG (0.74) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL17847409 | 0.83 | RARA (0.67) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL6535667 | 0.81 | RARG (0.74) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL1675424 | 0.81 | NPC1 (0.62) | HPSETTRALBMAOACNR1 | |
| Adapalene SCHEMBL4302240 | 0.80 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29357372 | 0.80 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29356474 | 0.80 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL2747 | 0.80 | RARB (1.00) | RARBRARGRARAMEN1KMT2A | |
| Adapalene SCHEMBL29393098 | 0.80 | RARB (1.00) | RARBRARGRARAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5260295-A | Retinoic acid derivatives, cosmetics, skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | claimed |
| US-5428052-A | Classifiable as retinoids; skin disorders, corneopathy | CENTRE INTERNATIONALE DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1995-06-27 | — | — | US | disclosed |
| US-5288744-A | Tetramethyltetrahydronaphthyl benzothiazole for treating skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1994-02-22 | — | — | US | disclosed |
| US-5260295-A | Retinoic acid derivatives, cosmetics, skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1993-11-09 | — | — | US | disclosed |
| US-5059621-A | Treatment of dermatologic ailments linked to keratinization disorder | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (C.I.R.D.) (FR) | 1991-10-22 | — | — | US | disclosed |
| US-4920140-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-04-24 | — | — | US | disclosed |
| US-4740519-A | Benzo (b) thiophene carboxylate derivatives and pharmaceutical compositions | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1988-04-26 | — | — | US | disclosed |