Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 5/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3773776 | 0.87 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL25488835 | 0.84 | MAOB (0.51) | SMN1; SMN2ALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL30455285 | 0.81 | SMN1; SMN2 (0.97) | SMN1; SMN2ALDH1A1MAPTEHMT2NSD2 | |
| SCHEMBL4092118 | 0.81 | SMN1; SMN2 (0.97) | SMN1; SMN2ALDH1A1MAPTEHMT2NSD2 | |
| SCHEMBL3318391 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1MAPTEHMT2NSD2 | |
| SCHEMBL9226427 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL4761451 | 0.80 | ACHE (0.67) | ADRA1DADRA1AADRA1B | |
| SCHEMBL3792399 | 0.79 | MAOB (0.54) | SMN1; SMN2ALDH1A1ADRA1DADRA1AADRA1B | |
| SCHEMBL9008378 | 0.79 | MAOB (0.54) | SMN1; SMN2ALDH1A1ADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL4760523 | 0.79 | ACHE (0.66) | ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5444062-A | Quinazolines derivatives for enhancing antitumor activity | PFIZER INC. (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0556310-B1 | QUINAZOLINES DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY | PFIZER (US) | 1995-07-05 | — | — | EP | disclosed |
| EP-0556310-A1 | QUINAZOLINES DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY. | PFIZER (US) | 1993-08-25 | — | — | EP | disclosed |
| WO-1992007844-A1 | QUINAZOLINES DERIVATIVES FOR ENHANCING ANTITUMOR ACTIVITY | PFIZER INC. (US) | 1992-05-14 | — | — | WO | disclosed |