Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | RAB9A | P51151 | 6/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314994 | 0.86 | KDM4E (0.80) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL1580942 | 0.83 | NPC1 (0.73) | GAAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27692836 | 0.82 | GAA (0.68) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL11745024 | 0.81 | GAA (0.67) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL8729336 | 0.79 | NPC1 (0.63) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL30598987 | 0.78 | KDM4E (0.76) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL26115749 | 0.78 | KDM4E (0.76) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL11712929 | 0.78 | NPC1 (0.73) | GAAMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2245547 | 0.77 | NPC1 (0.71) | GAACYP1A2MAPTNPC1RAB9A | |
| SCHEMBL32674581 | 0.77 | NPC1 (0.84) | GAAMAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | claimed |
| CN-101959516-B | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2013-05-08 | — | — | CN | disclosed |
| CN-101959516-A | Combination therapy comprising quinoxaline PI3K alpha inhibitors for the treatment of cancer | EXELIXIS INC | 2011-01-26 | — | — | CN | disclosed |
| US-5411967-A | Antiinflammatory, immunosuppressant, antitumor | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-02 | — | — | US | disclosed |