Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ASPH | Q12797 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14321783 | 0.90 | VNN1 (0.39) | PPARGVNN1EGFRJAK3BTK | |
| SCHEMBL14321784 | 0.90 | VNN1 (0.39) | PPARGVNN1EGFRJAK3BTK | |
| SCHEMBL13906 | 0.84 | MAPT (0.41) | VNN1EGFRJAK3BTKMEN1 | |
| SCHEMBL9909 | 0.84 | MAP2K4 (0.41) | VNN1EGFRJAK3BTKMEN1 | |
| SCHEMBL8781 | 0.83 | MAPT (0.41) | VNN1EGFRJAK3BTKMEN1 | |
| SCHEMBL8782 | 0.83 | MAPT (0.41) | VNN1EGFRJAK3BTKMEN1 | |
| SCHEMBL9137 | 0.81 | POLB (0.42) | VNN1EGFRJAK3BTKMEN1 | |
| SCHEMBL31544170 | 0.78 | KDM4E (0.47) | VNN1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL31544150 | 0.77 | APP (0.42) | VNN1EGFRMEN1KMT2AAPP | |
| SCHEMBL9405 | 0.76 | MEN1 (0.43) | EGFRMEN1KMT2AAPPPRUNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |