Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8782 | 0.93 | MAPT (0.41) | POLBMAPTKDM4EALDH1A1ATM | |
| SCHEMBL8781 | 0.93 | MAPT (0.41) | POLBMAPTKDM4EALDH1A1ATM | |
| SCHEMBL13906 | 0.89 | MAPT (0.41) | MAPTKDM4EALDH1A1RECQLTDP1 | |
| SCHEMBL9909 | 0.83 | MAP2K4 (0.41) | POLBMAPTJAK2TYK2VNN1 | |
| SCHEMBL31544170 | 0.83 | KDM4E (0.47) | MAPTKDM4EALDH1A1TDP1VNN1 | |
| SCHEMBL14321783 | 0.82 | VNN1 (0.39) | MAPTKDM4EALDH1A1TDP1VNN1 | |
| SCHEMBL14321784 | 0.82 | VNN1 (0.39) | MAPTKDM4EALDH1A1TDP1VNN1 | |
| SCHEMBL9136 | 0.81 | PPARG (0.39) | MAPTKDM4ETDP1VNN1MEN1 | |
| SCHEMBL9661 | 0.81 | ALDH1A1 (0.44) | POLBMAPTKDM4EALDH1A1RECQL | |
| SCHEMBL9660 | 0.81 | ALDH1A1 (0.44) | POLBMAPTKDM4EALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504315-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | Amgen Inc. (US) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011063233-A1 | AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2011-05-26 | — | — | WO | disclosed |