Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.30 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316284 | 0.98 | KDM4E (0.46) | KDM4EMAPTALDH1A1TDP1GAA | |
| SCHEMBL316437 | 0.81 | KDM4E (0.41) | KDM4EMAPTALDH1A1TDP1GAA | |
| Iodide SCHEMBL31063943 | 0.75 | KDM4E (0.46) | KDM4EMAPTALDH1A1TDP1GAA | |
| SCHEMBL4625831 | 0.75 | KDM4E (0.50) | KDM4EMAPTALDH1A1TDP1GAA | |
| Iodide SCHEMBL1318387 | 0.70 | MAPT (0.55) | KDM4EMAPTALDH1A1TDP1GAA | |
| Iodide SCHEMBL31147096 | 0.70 | MAPT (0.55) | KDM4EMAPTALDH1A1TDP1GAA | |
| SCHEMBL839316 | 0.67 | MAPT (0.52) | KDM4EMAPTALDH1A1TDP1GAA | |
| SCHEMBL30411778 | 0.67 | MAPT (0.52) | KDM4EMAPTALDH1A1TDP1GAA | |
| Bromide SCHEMBL4616453 | 0.66 | MAPT (0.51) | KDM4EMAPTALDH1A1TDP1GAA | |
| Hydrochloric Acid SCHEMBL4613932 | 0.66 | MAPT (0.50) | KDM4EMAPTALDH1A1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405968-A | Useful as drugs, for producing singlet oxygen, sensitizers in electrophotographic layers and for photopolymerizations and as laser light sensitive dyes in optical recording media | BASF AKTIENGESELLSCHAFT (DE) | 1995-04-11 | — | — | US | disclosed |