Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | FAAH | O00519 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9139288 | 0.91 | FAAH (0.50) | TDP1FAAHKMT2ARAB9A | |
| SCHEMBL8847851 | 0.84 | TSHR (0.65) | FAAHALDH1A1TSHR | |
| SCHEMBL3183513 | 0.80 | TSHR (0.68) | TDP1FAAHALDH1A1TSHRKMT2A | |
| SCHEMBL8848165 | 0.79 | HCAR2 (0.43) | TDP1ALDH1A1TSHRRAB9A | |
| SCHEMBL27540219 | 0.79 | TSHR (0.66) | TDP1FAAHALDH1A1TSHRKMT2A | |
| SCHEMBL9136464 | 0.79 | TDP1 (0.51) | TDP1FAAHALDH1A1TSHRKMT2A | |
| SCHEMBL22474206 | 0.78 | TDP1 (0.58) | TDP1FAAHALDH1A1TSHRKMT2A | |
| SCHEMBL27579434 | 0.78 | TDP1 (0.58) | TDP1FAAHALDH1A1TSHRKMT2A | |
| SCHEMBL7438421 | 0.77 | LMNA (0.50) | ALDH1A1KMT2ARAB9AMAPT | |
| SCHEMBL8847909 | 0.76 | FFAR1 (0.44) | ALDH1A1TSHRRAB9AFFAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459147-A | Angeotensin-antagonistic effects; hypotensive, antiischemic, and antidiabetic agents, treating glaucoma | DR. KARL THOMAE GMBH (DE) | 1995-10-17 | — | — | US | disclosed |
| EP-0560330-A2 | Substituted benzimidazolyl derivatives, therapeutic agents containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-09-15 | — | — | EP | disclosed |