Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | ACE | P12821 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.62 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.62 |
| ▸ | PDE4A | P27815 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9136081 | 0.94 | PPARG (0.63) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL9136803 | 0.87 | PPARG (0.69) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL1249924 | 0.85 | PPARG (0.78) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL2040839 | 0.85 | PPARG (0.67) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL9137178 | 0.84 | PPARG (0.65) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL9135348 | 0.84 | PPARG (0.58) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL13382771 | 0.83 | PPARG (0.75) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL9137086 | 0.83 | AGTR1 (0.57) | PPARGAGTR1AGTR2TP53MAPT | |
| SCHEMBL4362116 | 0.82 | PPARG (0.56) | PPARGKDM4EABCC3ABCC4USP2 | |
| SCHEMBL16456732 | 0.82 | PPARG (0.70) | PPARGKDM4EABCC3ABCC4USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459147-A | Angeotensin-antagonistic effects; hypotensive, antiischemic, and antidiabetic agents, treating glaucoma | DR. KARL THOMAE GMBH (DE) | 1995-10-17 | — | — | US | disclosed |
| EP-0560330-A2 | Substituted benzimidazolyl derivatives, therapeutic agents containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1993-09-15 | — | — | EP | disclosed |