SCHEMBL1249924

SCHEMBL1249924

CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 5/20 0.78
KDM4E B2RXH2 1/20 0.78
ABCC3 O15438 1/20 0.78
ABCC4 O15439 1/20 0.78
USP2 O75604 1/20 0.78
ABCB11 O95342 1/20 0.78
ALDH1A1 P00352 1/20 0.78
CHRM2 P08172 1/20 0.78
CYP3A4 P08684 1/20 0.78
ADRA2A P08913 1/20 0.78
ADORA3 P0DMS8 1/20 0.78
CHRM1 P11229 1/20 0.78
CYP2C9 P11712 1/20 0.78
ACE P12821 1/20 0.78
ADRA2C P18825 1/20 0.78
TBXA2R P21731 1/20 0.78
GLRA1 P23415 1/20 0.78
PDE4A P27815 1/20 0.78
HTR2A P28223 1/20 0.78
MAPK1 P28482 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13382771 0.94 PPARG (0.75) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL8268211 0.92 PPARG (0.80) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL9565910 0.91 PPARG (0.74) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL16456732 0.90 PPARG (0.70) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL12664495 0.90 PPARG (0.77) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL1249733 0.89 PPARG (0.76) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL9091775 0.89 PPARG (0.78) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL1249891 0.89 PPARG (0.76) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL4244974 0.89 PPARG (0.71) PPARGKDM4EABCC3ABCC4USP2
SCHEMBL809909 0.88 PPARG (0.78) PPARGKDM4EABCC3ABCC4USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2170835-A1 PROCESS FOR PREPARING TELMISARTAN Krka Tovarna Zdravil, D.D., Novo Mesto (SI) 2010-04-07 EP claimed
WO-2009004064-A1 PROCESS FOR PREPARING TELMISARTAN KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2009-01-08 WO claimed
EP-4719430-A1 COMBINATION TREATMENT AND/OR PREVENTION OF RENAL DISEASES AND/OR HYPERTENSION IN NON-HUMAN MAMMALS COMPRISING ONE OR MORE SGLT-2 INHIBITORS AND TELMISARTAN Boehringer Ingelheim Vetmedica GmbH (DE) 2026-04-08 EP disclosed
EP-4719429-A1 COMBINATION TREATMENT AND/OR PREVENTION OF CARDIAC DISEASES IN NON-HUMAN MAMMALS COMPRISING ONE OR MORE SGLT-2 INHIBITORS AND PIMOBENDAN AND/OR TELMISARTAN Boehringer Ingelheim Vetmedica GmbH (DE) 2026-04-08 EP disclosed
WO-2024240633-A1 COMBINATION TREATMENT AND/OR PREVENTION OF RENAL DISEASES AND/OR HYPERTENSION IN NON-HUMAN MAMMALS COMPRISING ONE OR MORE SGLT-2 INHIBITORS AND TELMISARTAN BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2024-11-28 WO disclosed
WO-2024240632-A1 COMBINATION TREATMENT AND/OR PREVENTION OF CARDIAC DISEASES IN NON-HUMAN MAMMALS COMPRISING ONE OR MORE SGLT-2 INHIBITORS AND PIMOBENDAN AND/OR TELMISARTAN BOEHRINGER INGELHEIM VETMEDICA GMBH (DE) 2024-11-28 WO disclosed
US-8993778-B2 Process for manufacture of telmisartan BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2015-03-31 US disclosed
EP-2279159-B1 2'-HALOBIPHENYL-4-YL INTERMEDIATES IN THE SYNTHESIS OF ANGIOTENSIN II ANTAGONISTS LEK PHARMACEUTICALS (SI) 2013-12-04 EP disclosed
US-20130137878-A1 PROCESS FOR MANUFACTURE OF TELMISARTAN BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2013-05-30 US disclosed
US-8410285-B2 2′-halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists LEK PHARMACEUTICALS D.D. (SI) 2013-04-02 US disclosed
EP-2443094-B1 PROCESS FOR THE PREPARATION OF TELMISARTAN KRKA TOVARNA ZDRAVIL D D NOVO MESTO (SI) 2013-03-20 EP disclosed
US-20100152259-A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS MERCK & CO INC. (US) 2010-06-17 US disclosed
EP-2170835-A1 PROCESS FOR PREPARING TELMISARTAN Krka Tovarna Zdravil, D.D., Novo Mesto (SI) 2010-04-07 EP disclosed
WO-2009115584-A2 2'-HALOBIPHENYL-4-YL INTERMEDIATES IN THE SYNTHESIS OF ANGIOTENSIN II ANTAGONISTS LEK PHARMACEUTICALS D.D. (SI) 2009-09-24 WO disclosed
EP-2103588-A1 2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists Lek Pharmaceuticals D.D. (SI) 2009-09-23 EP disclosed
EP-2103588-A1 2'-Halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists Lek Pharmaceuticals D.D. (SI) 2009-09-23 EP disclosed
WO-2009004064-A1 PROCESS FOR PREPARING TELMISARTAN KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO (SI) 2009-01-08 WO disclosed
EP-1144386-B1 TELMISARTAN POLYMORPHS, METHODS FOR PRODUCING SAME AND THEIR USE IN THE PREPARATION OF A MEDICAMENT BOEHRINGER INGELHEIM PHARMA (DE) 2003-10-22 EP disclosed
EP-1144386-A1 TELMISARTAN POLYMORPHS, METHODS FOR PRODUCING SAME AND THEIR USE IN THE PREPARATION OF A MEDICAMENT Boehringer Ingelheim Pharma KG (DE) 2001-10-17 EP disclosed
WO-2000043370-A1 TELMISARTAN POLYMORPHS, METHODS FOR PRODUCING SAME AND THEIR USE IN THE PREPARATION OF A MEDICAMENT BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-07-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130137878-A1 PROCESS FOR MANUFACTURE OF TELMISARTAN REN, ACE, AGT PPARG 2976/4885KDM4E 196/4885ABCC3 4183/4885
US-20100152259-A1 ANGIOTENSIN II RECEPTOR ANTAGONISTS AGTR1, AGTR2, REN PPARG 2546/4885KDM4E 1893/4885ABCC3 560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.