Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.31 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.31 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.31 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138225 | 0.97 | PDE4A (0.34) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8130743 | 0.85 | PDK2 (0.30) | PDK2 | |
| SCHEMBL9752997 | 0.83 | HSD11B1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8808216 | 0.82 | PSEN1 (0.41) | PDE4APDE4BPDE4CPDE4DPSEN1 | |
| SCHEMBL8132194 | 0.82 | PDK2 (0.33) | PDK2 | |
| SCHEMBL8807511 | 0.82 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DPDK2 | |
| SCHEMBL8807323 | 0.81 | LMNA (0.36) | PDE4APDE4BPDE4CPDE4DPDK2 | |
| SCHEMBL8812180 | 0.81 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4DPDK2 | |
| SCHEMBL8809865 | 0.80 | KDM4E (0.39) | PDE4APDE4BPDE4CPDE4DPDK2 | |
| SCHEMBL8810566 | 0.80 | PSEN1 (0.36) | PDE4APDE4BPDE4CPDE4DPSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470872-A | Benzopyranols | BEECHAM GROUP PLC (GB) | 1995-11-28 | — | — | US | claimed |
| EP-0376524-B1 | Benzopyran and related compounds | BEECHAM GROUP PLC (GB) | 1995-03-29 | — | — | EP | claimed |
| EP-0376524-A1 | Benzopyran and related compounds | BEECHAM GROUP PLC (GB) | 1990-07-04 | — | — | EP | claimed |
| US-5470872-A | Benzopyranols | BEECHAM GROUP PLC (GB) | 1995-11-28 | — | — | US | disclosed |
| EP-0376524-B1 | Benzopyran and related compounds | BEECHAM GROUP PLC (GB) | 1995-03-29 | — | — | EP | disclosed |
| EP-0633256-A1 | Benzopyran and related compounds | BEECHAM GROUP PLC (GB) | 1995-01-11 | — | — | EP | disclosed |
| EP-0376524-A1 | Benzopyran and related compounds | BEECHAM GROUP PLC (GB) | 1990-07-04 | — | — | EP | disclosed |