Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 1/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.55 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9141677 | 0.86 | PPARD (0.66) | FFAR1AKR1B1CYSLTR1ALOX5PPARG | |
| SCHEMBL8543204 | 0.81 | FFAR1 (0.57) | FFAR1AKR1B1MCL1CYSLTR1CYSLTR2 | |
| SCHEMBL27384853 | 0.77 | PLA2G2A (0.63) | LTB4RLTB4R2MCL1PPARGPPARD | |
| SCHEMBL9447703 | 0.76 | CYP1A2 (0.53) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9828391 | 0.76 | FFAR1 (0.73) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9053241 | 0.75 | CYSLTR1 (0.73) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL7807149 | 0.75 | FFAR1 (0.68) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL6092017 | 0.75 | CYSLTR1 (0.56) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 | |
| SCHEMBL9140666 | 0.75 | PLA2G2A (0.65) | ALOX5 | |
| SCHEMBL8625730 | 0.75 | FFAR1 (0.58) | FFAR1AKR1B1CYSLTR1CYSLTR2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229516-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-20 | — | — | US | claimed |
| EP-0502106-A1 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-09 | — | — | EP | claimed |
| WO-1991006537-A2 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | claimed |
| US-5420289-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS AND CYTOPROTECTIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-05-30 | — | — | US | disclosed |
| US-5229516-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |