Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.52 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.51 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9140666 | 0.87 | PLA2G2A (0.65) | CYP1A2ALOX5ALOX5AP | |
| SCHEMBL9447689 | 0.86 | PLA2G2A (0.56) | CYP1A2PDE10AALOX5CYSLTR1GPBAR1 | |
| SCHEMBL9680113 | 0.86 | ALOX5AP (0.62) | CYP1A2ALOX5ALOX5AP | |
| Water SCHEMBL9141761 | 0.86 | PLA2G2A (0.55) | CYP1A2PDE10AALOX5CYSLTR1GPBAR1 | |
| SCHEMBL9142609 | 0.86 | PLA2G2A (0.57) | CYP1A2PDE10AALOX5CYSLTR1GPBAR1 | |
| Water SCHEMBL9141768 | 0.86 | PLA2G2A (0.55) | CYP1A2PDE10AALOX5CYSLTR1GPBAR1 | |
| SCHEMBL9139743 | 0.86 | PLA2G2A (0.57) | CYP1A2PDE10AALOX5CYSLTR1GPBAR1 | |
| Water SCHEMBL9140717 | 0.85 | ALOX5AP (0.61) | CYP1A2ALOX5ALOX5AP | |
| Water SCHEMBL9140709 | 0.85 | ALOX5AP (0.61) | CYP1A2ALOX5ALOX5AP | |
| SCHEMBL2746925 | 0.84 | ALOX5AP (0.68) | CYP1A2ALOX5ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229516-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-20 | — | — | US | claimed |
| EP-0502106-A1 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-09-09 | — | — | EP | claimed |
| WO-1991006537-A2 | SUBSTITUTED INDOLE-, INDENE-, PYRANOINDOLE- AND TETRAHYDROCARBAZOLE- ALKANOIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-16 | — | — | WO | claimed |
| US-5229516-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |