SCHEMBL9144166

SCHEMBL9144166

Cc1ccc2nc(S)[nH]c2c1C

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 3/20 0.36
PDE3A Q14432 3/20 0.36
PDE2A O00408 1/20 0.36
P2RY12 Q9H244 1/20 0.36
KDM4E B2RXH2 2/20 0.35
MAPT P10636 2/20 0.35
MAPK1 P28482 1/20 0.35
DAO P14920 1/20 0.33
ALDH1A1 P00352 2/20 0.31
HPGD P15428 2/20 0.31
GAA P10253 1/20 0.31
RECQL P46063 1/20 0.31
HSD17B10 Q99714 1/20 0.31
NPC1 O15118 1/20 0.30
HTT P42858 1/20 0.30
RAB9A P51151 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14957165 0.98 PDE3B (0.35) PDE3BPDE3APDE2AP2RY12KDM4E
SCHEMBL353027 0.79 ALDH1A1 (0.41) PDE3BPDE3APDE2AP2RY12KDM4E
SCHEMBL2541923 0.76 FABP6 (0.46) PDE3BPDE3APDE2AP2RY12KDM4E
SCHEMBL22349154 0.76 KDM4E (0.43) PDE3BPDE3APDE2AP2RY12KDM4E
SCHEMBL3711999 0.76 DAO (0.37) PDE3BPDE3APDE2AP2RY12KDM4E
SCHEMBL14958069 0.76 MEN1 (0.34) KDM4EMAPTGAAHTTSMN1; SMN2
SCHEMBL110725 0.76 ALDH1A1 (0.41) PDE3BPDE3AMAPTDAOALDH1A1
SCHEMBL1524362 0.74 ALDH1A1 (0.40) PDE3BPDE3APDE2AMAPTDAO
SCHEMBL14957161 0.74 MEN1 (0.33) KDM4EMAPTGAAHTTSMN1; SMN2
SCHEMBL6757192 0.73 KDM4E (0.42) PDE3BPDE3APDE2AP2RY12KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111057269-B 2-thiothiazolinyl or 2-thioimidazolinyl terminated mercaptosilane coupling agent and synthesis method and application thereof 怡维怡橡胶研究院有限公司 2021-08-27 CN disclosed
US-8962720-B2 Rubber composition for golf ball BRIDGESTONE SPORTS CO., LTD. (JP) 2015-02-24 US disclosed
US-20130131236-A1 RUBBER COMPOSITION FOR GOLF BALL BRIDGESTONE CORPORATION (JP) 2013-05-23 US disclosed
US-RE35135-E Dental material; mixture of radical-polymerizable monomer, alpha-ketocarbonyl and aromatic amine MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1995-12-26 US disclosed
US-5091033-A ADHESIVE FOR CERAMICS AND PROCESSES FOR THE BONDING OF CERAMICS USING SAME MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1992-02-25 US disclosed
EP-0136186-B1 PHOTOCURABLE RESIN COMPOSITION MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-09-06 EP disclosed
EP-0252603-A2 Adhesives for ceramics and processes for the bonding of ceramics using same MITSUI SEKIYU KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1988-01-13 EP disclosed
US-4548689-A RADICAL POLYMERIZABLE MONOMER, KETOCARBONYL COMPOUND AND MERCAPTOB MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1985-10-22 US disclosed
EP-0136186-A2 Photocurable resin composition MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1985-04-03 EP disclosed