Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CTSD | P07339 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CASP2 | P42575 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9148420 | 0.83 | HSP90AA1 (0.56) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10431017 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9142802 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9148686 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10430758 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL10430870 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL9144976 | 0.81 | HSP90AA1 (0.59) | CES2CES1TSHRMEN1KMT2A | |
| SCHEMBL1643947 | 0.71 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6634673 | 0.71 | HDAC3 (0.63) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| Hydrochloric Acid SCHEMBL7640871 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378778-A | Liquid catalyst component, catalyst system containing the same, and process for producing ethylene-α-olefin copolymers using the catalyst system | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-01-03 | — | — | US | disclosed |
| EP-0395075-B1 | Liquid catalyst component, catalyst system containing the same, and process for producing ethylene-alpha-olefin copolymers using the catalyst system | SUMITOMO CHEMICAL CO (JP) | 1994-08-24 | — | — | EP | disclosed |
| EP-0395075-A2 | Liquid catalyst component, catalyst system containing the same, and process for producing ethylene-alpha-olefin copolymers using the catalyst system | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1990-10-31 | — | — | EP | disclosed |