Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.74 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL28414335 | 0.89 | CRBN (0.77) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL8235 | 0.86 | — | — | |
| Uracil SCHEMBL5089507 | 0.86 | — | — | |
| Uracil SCHEMBL3798527 | 0.86 | CRBN (1.00) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL11607890 | 0.86 | — | — | |
| Uracil SCHEMBL28426792 | 0.84 | CRBN (0.85) | CRBNMMP2TP53TYMPGSK3B | |
| Uracil SCHEMBL2161716 | 0.84 | — | — | |
| Uracil SCHEMBL8767625 | 0.84 | — | — | |
| Uracil SCHEMBL21385227 | 0.84 | — | — | |
| Uracil SCHEMBL4664232 | 0.84 | CRBN (0.94) | CRBNMMP2TP53TYMPGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0654998-A1 | METHOD OF NEUTRALIZING IL-1 USING dsRNAs | HEM PHARMACEUTICALS CORP. (US) | 1995-05-31 | — | — | EP | claimed |
| EP-0654998-A4 | METHOD OF NEUTRALIZING IL-1 USING dsRNAs. | HEM PHARMA CORP (US) | 1995-01-11 | — | — | EP | claimed |
| US-5258369-A | Administering polynucleotides, cognition activators | HEM PHARMACEUTICALS CORPORATION (US) | 1993-11-02 | — | — | US | claimed |
| WO-1993005788-A1 | METHOD OF NEUTRALIZING IL-1 USING dsRNAs | HEM PHARMACEUTICALS CORP. (US) | 1993-04-01 | — | — | WO | claimed |
| CN-1059659-A | The diagnosis of viral hepatitis and treatment | HEM RES INC (US) | 1992-03-25 | — | — | CN | claimed |