Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.57 |
| ▸ | LDHB | P07195 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | BLM | P54132 | 3/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL26926567 | 0.88 | LMNA (0.54) | LDHALDHBLMNABLMPMP22 | |
| SCHEMBL598557 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL28385699 | 0.84 | — | — | |
| Pyruvate SCHEMBL21145072 | 0.84 | — | — | |
| Pyruvate SCHEMBL23829857 | 0.83 | — | — | |
| Pyruvate SCHEMBL274319 | 0.83 | TSHR (0.60) | LDHALDHBLMNABLMPMP22 | |
| Pyruvate SCHEMBL8710299 | 0.83 | — | — | |
| Pyruvate SCHEMBL8710301 | 0.83 | TSHR (0.60) | LDHALDHBLMNABLMPMP22 | |
| Pyruvate SCHEMBL13165964 | 0.83 | — | — | |
| Pyruvate SCHEMBL1331078 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5472980-A | Reducing insulin resistance in mammals with amino acid derivatives | ABBOTT LABORATORIES (US) | 1995-12-05 | — | — | US | disclosed |
| US-5312985-A | Reaction of sodium pyruvate with thionyl chloride and oxalyl chloride to form pyruvyl chloride, then reaction with 1,1,1,3,3,3-hexamethyldisilazane and methanol to form pyruvamide | ABBOTT LABORATORIES (US) | 1994-05-17 | — | — | US | disclosed |
| US-5283260-A | Oral ingesting a pyruvyl-amino acid compound before a glucose tolerance test | ABBOTT LABORATORIES (US) | 1994-02-01 | — | — | US | disclosed |
| US-5256697-A | Covalently linked pyruvyl-amino compound | ABBOTT LABORATORIES | 1993-10-26 | — | — | US | disclosed |