Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 8/20 | 0.53 |
| ▸ | HRH2 | P25021 | 4/20 | 0.53 |
| ▸ | QPCT | Q16769 | 4/20 | 0.48 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7424829 | 0.87 | HRH4 (0.53) | HRH4HRH2QPCTNAMPT | |
| SCHEMBL9148294 | 0.84 | HRH4 (0.50) | HRH4HRH2QPCTNAMPT | |
| SCHEMBL7356849 | 0.82 | NAMPT (0.60) | HRH4HRH2QPCTNAMPTCYP3A4 | |
| SCHEMBL8620026 | 0.81 | HRH4 (0.50) | HRH4HRH2QPCTNAMPT | |
| SCHEMBL7353954 | 0.81 | HRH4 (0.52) | HRH4HRH2QPCTNAMPTMAPKAPK2 | |
| SCHEMBL9147554 | 0.78 | HRH4 (0.43) | HRH4HRH2NAMPTCYP3A4CYP2C9 | |
| SCHEMBL7430610 | 0.77 | HRH4 (0.52) | HRH4HRH2QPCTNAMPT | |
| SCHEMBL7350535 | 0.74 | NAMPT (0.62) | HRH4HRH2QPCTNAMPTCYP3A4 | |
| SCHEMBL7423091 | 0.74 | NAMPT (0.59) | HRH4HRH2QPCTNAMPTMAPKAPK2 | |
| SCHEMBL7360003 | 0.73 | P2RX7 (0.61) | HRH4HRH2QPCTNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | claimed |
| EP-0655057-A1 | CYANOGUANIDINES AS POTASSIUM CHANNEL BLOCKERS. | UPJOHN CO (US) | 1995-05-31 | — | — | EP | disclosed |