Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 3/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21004267 | 0.85 | CDK2 (0.50) | CDK2KCNH2SCN9ASYKGSK3B | |
| SCHEMBL14088796 | 0.82 | AURKA (0.72) | CDK2MAPK8AURKACDK4LMNA | |
| SCHEMBL10225814 | 0.81 | SCN9A (0.58) | CDK2KCNH2SCN9ASYKAURKA | |
| SCHEMBL84402 | 0.80 | KCNH2 (0.54) | CDK2KCNH2SCN9ASYKGSK3B | |
| SCHEMBL10224745 | 0.78 | CRHR1 (0.49) | SORT1CDK1MEN1MAPTKMT2A | |
| SCHEMBL19575358 | 0.78 | AURKA (0.57) | CDK2KCNH2SCN9ASYKAURKA | |
| SCHEMBL22628094 | 0.78 | NPC1 (0.45) | CDK2KCNH2SCN9ASYKAURKA | |
| SCHEMBL4624975 | 0.78 | NPC1 (0.65) | CDK2SYKAURKACDK1CDK4 | |
| SCHEMBL28037898 | 0.78 | KCNH2 (0.54) | CDK2KCNH2SCN9ASYKMAPK8 | |
| SCHEMBL13524613 | 0.77 | GSK3B (0.55) | CDK2GSK3BCDK4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | CDK2 20/4885KCNH2 4723/4885SCN9A 4830/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | CDK2 34/4885KCNH2 4229/4885SCN9A 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.