Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | AURKA | O14965 | 4/20 | 0.65 |
| ▸ | CDK2 | P24941 | 3/20 | 0.65 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.65 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.65 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.65 |
| ▸ | PRKCG | P05129 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10225814 | 0.85 | SCN9A (0.58) | NPC1RAB9AAURKACDK2PRKCD | |
| SCHEMBL14088797 | 0.82 | PIK3CA (0.62) | AURKACDK2CHEK1PDPK1CHEK2 | |
| SCHEMBL19575358 | 0.81 | AURKA (0.57) | NPC1RAB9AAURKACDK2IKBKB | |
| SCHEMBL22628094 | 0.81 | NPC1 (0.45) | NPC1RAB9AAURKACDK2PRKCD | |
| Pyrimethanil SCHEMBL1467035 | 0.81 | SMN1; SMN2 (0.61) | NPC1RAB9AAURKACDK2PRKCD | |
| SCHEMBL15185772 | 0.81 | PLK1 (0.52) | NPC1RAB9AAURKACDK2CDK4 | |
| SCHEMBL14088792 | 0.81 | JAK2 (0.57) | NPC1RAB9AAURKAPRKCDCHEK2 | |
| SCHEMBL14088791 | 0.81 | ALDH1A1 (0.82) | MAPTMAPK1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL24507552 | 0.80 | ABL1 (0.62) | NPC1RAB9ACDK2MAPTCDK4 | |
| SCHEMBL91451 | 0.80 | SMN1; SMN2 (0.67) | NPC1RAB9AAURKACDK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5065205-A | — | — | None | — | — | JP | disclosed |
| JP-6293608-A | — | — | None | — | — | JP | disclosed |
| CN-107721991-B | A kind of 6- (pyrimidine-4-yl) -1H- indazole derivative and its preparation method and application | 南方医科大学中西医结合医院 | 2019-10-18 | — | — | CN | disclosed |
| WO-2019038389-A1 | PYRIDINAMINE-PYRIDONE AND PYRIMIDINAMINE-PYRIDONE COMPOUNDS | SPRINT BIOSCIENCE AB (SE) | 2019-02-28 | — | — | WO | disclosed |
| US-10005737-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2018-06-26 | — | — | US | disclosed |
| CN-107721991-A | A kind of 6 (base of pyrimidine 4) 1H indazole derivatives and its preparation method and application | 南方医科大学中西医结合医院 | 2018-02-23 | — | — | CN | disclosed |
| US-20170073315-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2017-03-16 | — | — | US | disclosed |
| US-9533959-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160159749-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | VERTEX PHARMACEUTICALS (EUROPE) LIMITED (GB) | 2016-06-09 | — | — | US | disclosed |
| US-9296727-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-03-29 | — | — | US | disclosed |
| US-7163945-B2 | Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase | PHARMIX CORP. (US) | 2007-01-16 | — | — | US | disclosed |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2007-01-04 | — | — | US | disclosed |
| CN-1264406-C | Synergetic fungicide composition comprising pyrimethanil and at least a phosphorous acid derivative and use thereof for fighting against plant diseases | BAYER CROPSCIENCE SA (FR) | 2006-07-19 | — | — | CN | disclosed |
| CN-1582115-A | Synergetic fungicide composition comprising pyrimethanil and at least a phosphorous acid derivative and use thereof for fighting against plant diseases | BAYER CROPSCIENCE SA (FR) | 2005-02-16 | — | — | CN | disclosed |
| US-20050019420-A1 | Fungicide composition comprising pyrimethanil and at least a phosphorous acid derivative and use thereof for fighting against plant diseases | BAYER CROPSCIENCE S.A. (FR) | 2005-01-27 | — | — | US | disclosed |
| EP-1441590-A1 | FUNGICIDE COMPOSITION COMPRISING PYRIMETHANIL AND AT LEAST A PHOSPHOROUS ACID DERIVATIVE AND USE THEREOF FOR FIGHTING AGAINST PLANT DISEASES | Bayer CropScience S.A. (FR) | 2004-08-04 | — | — | EP | disclosed |
| WO-2003039257-A1 | FUNGICIDE COMPOSITION COMPRISING PYRIMETHANIL AND AT LEAST A PHOSPHOROUS ACID DERIVATIVE AND USE THEREOF FOR FIGHTING AGAINST PLANT DISEASES | BAYER CROPSCIENCE S.A. (FR) | 2003-05-15 | — | — | WO | disclosed |
| JP-H06293608-A | AGROCULTURAL AND HORTICULTURAL GERMICIDAL COMPOSITION | KUMIAI CHEM IND CO LTD | 1994-10-21 | — | — | JP | disclosed |
| JP-H0565205-A | AGRICULTURAL/HORTICULTURAL BACTERICIDAL COMPOSITION | KUMIAI CHEM IND CO LTD | 1993-03-19 | — | — | JP | disclosed |
| JP-H00565205-A | — | — | 0001-01-01 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170073315-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | TYMS, UMPS, DPYD | NPC1 3666/4885RAB9A 3238/4885AURKA 729/4885 |
| US-20070004758-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | NPC1 619/4885RAB9A 3952/4885AURKA 1175/4885 |
| US-20160159749-A1 | METHODS OF REGIOSELECTIVE SYNTHESIS OF 2,4-DISUBSTITUTED PYRIMIDINES | TYMS, UMPS, DPYD | NPC1 3666/4885RAB9A 3238/4885AURKA 729/4885 |
| US-10005737-B2 | Methods of regioselective synthesis of 2,4-disubstituted pyrimidines | TYMS, UMPS, DPYD | NPC1 3666/4885RAB9A 3238/4885AURKA 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.