SCHEMBL9148263

SCHEMBL9148263

CN(C)CCCCCCCc1ccc(C(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.56
THRA P10827 3/20 0.54
THRB P10828 3/20 0.54
GAA P10253 2/20 0.52
SIGMAR1 Q99720 1/20 0.51
KCNH2 Q12809 4/20 0.50
TSHR P16473 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
HRH3 Q9Y5N1 1/20 0.45
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9147259 0.86 SIGMAR1 (0.67) THRATHRBSIGMAR1KCNH2HDAC1
SCHEMBL9151024 0.86 SIGMAR1 (0.67) THRATHRBSIGMAR1KCNH2HDAC1
SCHEMBL9148170 0.86 SIGMAR1 (0.67) THRATHRBSIGMAR1KCNH2HDAC1
SCHEMBL9147658 0.86 SIGMAR1 (0.67) THRATHRBSIGMAR1KCNH2HDAC1
SCHEMBL9154254 0.85 RAB9A (0.51) BCL2L1THRATHRBGAASIGMAR1
SCHEMBL2277966 0.85 SIGMAR1 (0.62) BCL2L1SIGMAR1KCNH2TSHRL3MBTL1
SCHEMBL9146978 0.85 TAAR1 (0.54) THRATHRBSIGMAR1KCNH2L3MBTL1
SCHEMBL9152006 0.85 TAAR1 (0.54) THRATHRBSIGMAR1KCNH2POLB
Hydrochloric Acid SCHEMBL9154562 0.84 TAAR1 (0.53) THRATHRBSIGMAR1KCNH2POLB
SCHEMBL9151142 0.82 SIGMAR1 (0.53) BCL2L1THRATHRBSIGMAR1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0401798-B1 Substituted aminoalkylbenzene derivatives HOFFMANN LA ROCHE (CH) 1995-01-11 EP disclosed
US-5137920-A METHOD OF TREATING FUNGAL INFECTIONS HOFFMANN-LA ROCHE INC. (US) 1992-08-11 US disclosed