Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.53 |
| ▸ | MAOA | P21397 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9145505 | 1.00 | KDM1A (0.53) | KDM1AMAOAMAOBGID4HTR2C | |
| SCHEMBL9144599 | 0.85 | GID4 (0.54) | KDM1AMAOAMAOBGID4HTR2C | |
| SCHEMBL9271783 | 0.76 | KDM1A (0.44) | KDM1AMAOAMAOBGID4NPC1 | |
| SCHEMBL14489184 | 0.73 | GID4 (0.50) | KDM1AMAOAGID4NPC1TP53 | |
| SCHEMBL10876008 | 0.73 | GID4 (0.47) | KDM1AMAOAMAOBGID4CACNA1S | |
| SCHEMBL13598955 | 0.72 | NQO2 (0.52) | KDM1AMAOAMAOBEDNRAEDNRB | |
| SCHEMBL9147856 | 0.71 | KDM1A (0.51) | KDM1AMAOAMAOBGID4 | |
| SCHEMBL5729043 | 0.70 | KDM1A (1.00) | KDM1AMAOAMAOBHTR2C | |
| SCHEMBL7094099 | 0.70 | KDM1A (1.00) | KDM1AMAOAMAOBHTR2C | |
| SCHEMBL6755876 | 0.70 | KDM1A (1.00) | KDM1AMAOAMAOBHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5416118-A | Enzyme inhibitors | SCHERING CORPORATION (US) | 1995-05-16 | — | — | US | disclosed |
| EP-0583346-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1994-02-23 | — | — | EP | disclosed |
| WO-1992018462-A1 | BICYCLIC AMIDES AS INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL ACYL TRANSFERASE | SCHERING CORPORATION (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0508425-A1 | Bicyclic amides as inhibitors of acyl-coenzyme a: cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-10-14 | — | — | EP | disclosed |