Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9148823 | 1.00 | TSHR (0.36) | TSHRKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL9148812 | 1.00 | TSHR (0.36) | TSHRKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL19010647 | 0.79 | TSHR (0.39) | TSHRKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL9939509 | 0.79 | TSHR (0.39) | TSHRKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL8873316 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2 | |
| SCHEMBL11084180 | 0.76 | KDM4E (0.47) | TSHRKDM4ESMN1; SMN2 | |
| SCHEMBL10774433 | 0.75 | TSHR (0.48) | TSHRKDM4EBRD4SMN1; SMN2 | |
| SCHEMBL7515872 | 0.75 | BCHE (0.34) | KDM4ESMN1; SMN2 | |
| SCHEMBL7860321 | 0.75 | BCHE (0.34) | KDM4ESMN1; SMN2 | |
| SCHEMBL16199661 | 0.74 | JAK2 (0.38) | TSHRBRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| US-5260293-A | Simulate central muscarinic acetlycholine receptors | MERCK SHARP & DOHME LIMITED (GB) | 1993-11-09 | — | — | US | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |