Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.57 |
| ▸ | MMP8 | P22894 | 1/20 | 0.57 |
| ▸ | MMP14 | P50281 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MPO | P05164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5343010 | 0.94 | GFER (0.62) | GFERHSD17B10SLC6A4HTR2ATRPM8 | |
| SCHEMBL892530 | 0.91 | HPGD (0.69) | GFERHSD17B10SLC6A4HTR2ATRPM8 | |
| SCHEMBL1614234 | 0.89 | SLC6A4 (0.60) | GFERHSD17B10SLC6A4HTR2ATRPM8 | |
| SCHEMBL27774062 | 0.87 | GFER (0.53) | GFERHSD17B10SLC6A4HTR2ATRPM8 | |
| SCHEMBL1270126 | 0.84 | NPSR1 (0.68) | HSD17B10SLC6A4HTR2AHPGDCYP2C19 | |
| SCHEMBL7238856 | 0.84 | GFER (0.66) | GFERHSD17B10SLC6A4HTR2ATRPM8 | |
| SCHEMBL10344751 | 0.83 | MTNR1A (0.61) | GFERSLC6A4HTR2AMTNR1AMTNR1B | |
| SCHEMBL31173807 | 0.83 | SLC6A4 (0.60) | SLC6A4HTR2ATRPM8MTNR1AMTNR1B | |
| SCHEMBL5203631 | 0.83 | MPO (0.80) | SLC6A4HTR2ATRPM8MTNR1AMTNR1B | |
| SCHEMBL6365589 | 0.83 | SLC6A4 (0.60) | GFERHSD17B10SLC6A4HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516849-B1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5283251-A | Testosterone 5a-reductase inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-02-01 | — | — | US | disclosed |
| EP-0516849-A1 | INDOLE DERIVATIVES. | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-12-09 | — | — | EP | disclosed |
| WO-1991013060-A1 | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-09-05 | — | — | WO | disclosed |
| CN-1054250-A | INDOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-09-04 | — | — | CN | disclosed |