Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 1.00 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 3/20 | 0.53 |
| ▸ | CA1 | P00915 | 8/20 | 0.47 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA4 | P22748 | 7/20 | 0.47 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142557 | 0.96 | PLK1 (0.93) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL22980483 | 0.88 | PLK1 (0.79) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL9533936 | 0.86 | PLK1 (0.74) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL9534422 | 0.80 | PLK1 (0.65) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL1543821 | 0.78 | CSNK2A1 (0.64) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL9149384 | 0.78 | PLK1 (0.63) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL22349291 | 0.77 | PLK1 (0.62) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL366643 | 0.77 | PLK1 (0.62) | PLK1CSNK2A1PLK3HTTELANE | |
| SCHEMBL9535703 | 0.77 | PLK1 (0.61) | PLK1CSNK2A1PLK3CYP11B2ALDH1A1 | |
| SCHEMBL9142953 | 0.77 | PLK1 (0.62) | PLK1CSNK2A1PLK3HTTELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250109139-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES (CN) | 2025-04-03 | — | — | US | disclosed |
| CN-112424195-B | Fused lactam derivatives | 住友制药株式会社 | 2025-03-25 | — | — | CN | disclosed |
| US-20250084090-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2025-03-13 | — | — | US | disclosed |
| US-12180213-B2 | Substituted pyrazoles showing serotonin 5-HT receptor activity | SUMITOMO PHARMA CO. LTD. (JP) | 2024-12-31 | — | — | US | disclosed |
| US-20230276802-A1 | Method for Controlling Hematophagous or Sap-Feeding Arthropods | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSTIY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2023-09-07 | — | — | US | disclosed |
| WO-2023143393-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海科技大学 | 2023-08-03 | — | — | WO | disclosed |
| CN-116514824-A | Tri-ring compound, preparation method and application thereof | 上海科技大学 | 2023-08-01 | — | — | CN | disclosed |
| US-11632953-B2 | Method for controlling hematophagous or sap-feeding arthropods | BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE (US) | 2023-04-25 | — | — | US | disclosed |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | Sumitomo Pharma Co., Ltd. (JP) | 2023-01-12 | — | — | US | disclosed |
| WO-2005063764-A2 | FUSED PYRROLOCARBAZOLES AND METHODS FOR THE PREPARATION THEREOF | CEPHALON, INC. (US) | 2005-07-14 | — | — | WO | disclosed |
| EP-0590558-B1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | THOMAE GMBH DR K (DE) | 1995-12-06 | — | — | EP | disclosed |
| US-5468766-A | Analgesics, antipyretics, antiphlogistics | DR. KARL THOMAE GMBH (DE) | 1995-11-21 | — | — | US | disclosed |
| EP-0276833-B1 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMA (US) | 1995-02-15 | — | — | EP | disclosed |
| EP-0590558-A1 | Pharmaceutical composition containing 1,5,6,7-tetrahydro-4H-indazol-4-ones,new 1,5,6,7-tetrahydro-4H-indazol-4-ones and process for their manufacture | Dr. Karl Thomae GmbH (DE) | 1994-04-06 | — | — | EP | disclosed |
| EP-0276834-B1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-02 | — | — | EP | disclosed |
| EP-0276833-A2 | Dipyrazoles useful as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| EP-0276834-A1 | Cycloalkane [1,2-c:4,3-c'] dipyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734429-A | Cycloalkane[1,2-c:4,3-c']dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |
| US-4734430-A | Dipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250084090-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | PLK1 1447/4885CSNK2A1 1326/4885PLK3 2881/4885 |
| US-12180213-B2 | Substituted pyrazoles showing serotonin 5-HT receptor activity | HTR5A, HTR1A, TPH1 | PLK1 1277/4885CSNK2A1 1289/4885PLK3 988/4885 |
| US-11632953-B2 | Method for controlling hematophagous or sap-feeding arthropods | KCNN1, KCNN2, KCNN3 | PLK1 1496/4885CSNK2A1 3338/4885PLK3 3083/4885 |
| US-20250109139-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | PARK7, HADH, BDNF | PLK1 2719/4885CSNK2A1 3439/4885PLK3 4064/4885 |
| US-20230008875-A1 | SUBSTITUTED LACTAMS SHOWING SEROTONIN 5-HT RECEPTOR ACTIVITY | HTR1A, HTR5A, TPH1 | PLK1 1447/4885CSNK2A1 1326/4885PLK3 2881/4885 |
| US-20230276802-A1 | Method for Controlling Hematophagous or Sap-Feeding Arthropods | KCNN1, KCNN2, KCNN3 | PLK1 1496/4885CSNK2A1 3338/4885PLK3 3083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.