Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.53 |
| ▸ | ELANE | P08246 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 8/20 | 0.41 |
| ▸ | CA2 | P00918 | 8/20 | 0.41 |
| ▸ | CA4 | P22748 | 8/20 | 0.41 |
| ▸ | CA9 | Q16790 | 7/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9142953 | 0.79 | PLK1 (0.62) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL3531363 | 0.76 | PLK1 (0.58) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL9149384 | 0.76 | PLK1 (0.63) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL17895891 | 0.76 | PLK1 (0.57) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL6663384 | 0.73 | ELANE (0.55) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL3536391 | 0.70 | PLK1 (0.50) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL1986758 | 0.69 | PLK1 (1.00) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL366643 | 0.69 | PLK1 (0.62) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL700290 | 0.69 | ELANE (0.51) | PLK1CSNK2A1PLK3ELANEHTT | |
| SCHEMBL21003834 | 0.69 | PLK1 (0.49) | PLK1CSNK2A1PLK3ELANEHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177185-A1 | 4, 5, 6, 7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000069846-A1 | 4,5,6,7-TETRAHYDROINDAZOLE DERIVATIVES AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-11-23 | — | — | WO | disclosed |