Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580736 | 0.87 | HTR6 (0.61) | HTR6HTR2AKCNH2HTR1A | |
| Hydrochloric Acid SCHEMBL27751697 | 0.87 | HTR6 (0.61) | HTR6HTR2AKCNH2HTR1A | |
| SCHEMBL9147029 | 0.87 | HTR6 (0.56) | HTR6KCNH2 | |
| SCHEMBL9462735 | 0.87 | HTR6 (0.68) | HTR6DRD3HTR2AHTR2CKCNH2 | |
| SCHEMBL9149499 | 0.83 | HTR6 (0.52) | HTR6DRD3HTR2CHTR1AKHK | |
| SCHEMBL9149428 | 0.83 | HTR6 (0.52) | HTR6DRD3HTR2AHTR2CHTR1A | |
| SCHEMBL10874677 | 0.82 | HTR6 (0.57) | HTR6DRD3HTR2AHTR2CHTR1A | |
| SCHEMBL9146903 | 0.82 | HTR6 (0.51) | HTR6DRD3HTR2CHTR1AKHK | |
| SCHEMBL9462566 | 0.82 | HTR6 (0.56) | HTR6DRD3HTR2CKCNH2HTR1A | |
| SCHEMBL9150292 | 0.81 | HTR6 (0.50) | HTR6DRD3HTR1AKHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5457115-A | Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans | H. LUNDBECK A/S (DK) | 1995-10-10 | — | — | US | disclosed |
| EP-0465398-B1 | Novel indole derivatives | LUNDBECK & CO AS H (DK) | 1994-12-14 | — | — | EP | disclosed |
| US-5322851-A | Indole derivatives | H. LUNDBECK A/S (DK) | 1994-06-21 | — | — | US | disclosed |
| US-5216001-A | Central nervous system disorders | H. LUNBECK A/S (DK) | 1993-06-01 | — | — | US | disclosed |
| EP-0465398-A2 | Novel indole derivatives | H. LUNDBECK A/S (DK) | 1992-01-08 | — | — | EP | disclosed |