Sugi Predict

Sugi Predict / Compounds / SCHEMBL9150811

SCHEMBL9150811

SCHEMBL9150811

CS(=O)(=O)c1ccc2c(C3=CCNCC3)cn(-c3ccc(F)cc3)c2c1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 19/20 0.60
▸ HTR1A P08908 3/20 0.47
▸ HTR7 P34969 1/20 0.47
▸ DRD3 P35462 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9149428 0.84 HTR6 (0.52) HTR6HTR1AHTR7DRD3
SCHEMBL9149499 0.82 HTR6 (0.52) HTR6HTR1ADRD3
SCHEMBL9147029 0.82 HTR6 (0.56) HTR6
SCHEMBL9462735 0.81 HTR6 (0.68) HTR6HTR1AHTR7DRD3
SCHEMBL9150978 0.81 HTR6 (0.51) HTR6HTR1AHTR7DRD3
SCHEMBL9150228 0.81 HTR6 (0.49) HTR6HTR1ADRD3
SCHEMBL9146903 0.81 HTR6 (0.51) HTR6HTR1ADRD3
SCHEMBL9150425 0.81 HTR6 (0.55) HTR6HTR1ADRD3
SCHEMBL9150292 0.80 HTR6 (0.50) HTR6HTR1ADRD3
SCHEMBL9150236 0.80 HTR6 (0.50) HTR6HTR1ADRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5457115-A Treating anxiety, depression, sleep disorders, migranes, schizophrenia or Parkinson's disease in humans H. LUNDBECK A/S (DK) 1995-10-10 — — US disclosed
US-5322851-A Indole derivatives H. LUNDBECK A/S (DK) 1994-06-21 — — US disclosed
US-5216001-A Central nervous system disorders H. LUNBECK A/S (DK) 1993-06-01 — — US disclosed