Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 11/20 | 0.73 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149226 | 0.85 | LTB4R (0.58) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL7972701 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2ALDH1A1HPGD | |
| SCHEMBL9147969 | 0.84 | LTB4R (0.72) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL7449678 | 0.83 | LTB4R (0.48) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9150020 | 0.82 | LTB4R (0.71) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9150347 | 0.81 | LTB4R (0.76) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL9150788 | 0.78 | LTB4R (0.47) | LTB4RLTB4R2KDM4EALDH1A1HPGD | |
| SCHEMBL11768877 | 0.78 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL11771151 | 0.78 | LTB4R (0.51) | LTB4RLTB4R2 | |
| SCHEMBL11769105 | 0.78 | LTB4R (0.51) | LTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442748-B1 | Improvements in and relating to leukotriene antagonists | LILLY CO ELI (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0442748-A1 | Improvements in and relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996230-A | Antiallergens, antiinflammatory agent | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |