Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 13/20 | 0.76 |
| ▸ | LTB4R2 | Q9NPC1 | 8/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9149226 | 0.88 | LTB4R (0.58) | LTB4RLTB4R2TSHRKDM4EALDH1A1 | |
| SCHEMBL30410852 | 0.87 | LTB4R (1.00) | LTB4RLTB4R2DRD3KDM4EALDH1A1 | |
| SCHEMBL9148299 | 0.87 | LTB4R (1.00) | LTB4RLTB4R2DRD3KDM4EALDH1A1 | |
| SCHEMBL9148303 | 0.87 | LTB4R (1.00) | LTB4RLTB4R2DRD3KDM4EALDH1A1 | |
| SCHEMBL9150895 | 0.81 | LTB4R (0.73) | LTB4RLTB4R2TSHRKDM4EALDH1A1 | |
| SCHEMBL9154604 | 0.81 | LTB4R (0.53) | LTB4RLTB4R2DRD3TSHRKDM4E | |
| SCHEMBL9154611 | 0.81 | LTB4R (0.53) | LTB4RLTB4R2DRD3TSHRKDM4E | |
| SCHEMBL9150788 | 0.77 | LTB4R (0.47) | LTB4RLTB4R2TSHRKDM4EALDH1A1 | |
| SCHEMBL9150723 | 0.73 | LTB4R (0.76) | LTB4RLTB4R2DRD3KDM4EALDH1A1 | |
| SCHEMBL7449678 | 0.72 | LTB4R (0.48) | LTB4RLTB4R2TSHRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442748-B1 | Improvements in and relating to leukotriene antagonists | LILLY CO ELI (US) | 1995-01-11 | — | — | EP | disclosed |
| EP-0442748-A1 | Improvements in and relating to leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1991-08-21 | — | — | EP | disclosed |
| US-4996230-A | Antiallergens, antiinflammatory agent | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |