SCHEMBL9150964

SCHEMBL9150964

CCc1nn(C)c(C(=O)NCCOc2ccc(CCOC)cc2C)c1Br

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 3/20 0.41
KMT2A Q03164 4/20 0.40
KDM4E B2RXH2 4/20 0.40
ALDH1A1 P00352 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
HPGD P15428 1/20 0.39
HRH3 Q9Y5N1 5/20 0.38
MAPT P10636 4/20 0.37
PDE5A O76074 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MEN1 O00255 1/20 0.36
POLB P06746 1/20 0.35
LMNA P02545 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8759402 0.90 KMT2A (0.41) KMT2AKDM4EALDH1A1L3MBTL1HPGD
SCHEMBL9150666 0.83 MAPT (0.39) TP53KMT2AALDH1A1L3MBTL1HPGD
SCHEMBL8759340 0.82 KMT2A (0.52) KMT2AKDM4EALDH1A1L3MBTL1HPGD
SCHEMBL9151184 0.82 LMNA (0.43) TP53KMT2AKDM4EALDH1A1L3MBTL1
SCHEMBL9148274 0.78 LMNA (0.40) TP53KMT2AKDM4EALDH1A1L3MBTL1
SCHEMBL9786716 0.77 KDM4E (0.39) KMT2AKDM4EALDH1A1L3MBTL1HPGD
SCHEMBL8760420 0.76 SMN1; SMN2 (0.49) TP53KMT2AKDM4EALDH1A1L3MBTL1
SCHEMBL9166168 0.76 GALR3 (0.46) KDM4EALDH1A1L3MBTL1HPGDHRH3
SCHEMBL9151802 0.75 LMNA (0.48) TP53KMT2AKDM4EALDH1A1L3MBTL1
SCHEMBL8760383 0.75 MTNR1A (0.51) KMT2AKDM4EALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0405808-B1 Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides UBE INDUSTRIES (JP) 1995-01-11 EP claimed
US-5039692-A Phenoxyalkylamine derivatives, and insecticides, acaricides and fungicides UBE INDUSTRIES, LTD. (JP) 1991-08-13 US claimed
EP-0405808-A1 Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides UBE INDUSTRIES, LTD. (JP) 1991-01-02 EP claimed
EP-0405808-B1 Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides UBE INDUSTRIES (JP) 1995-01-11 EP disclosed
US-5039692-A Phenoxyalkylamine derivatives, and insecticides, acaricides and fungicides UBE INDUSTRIES, LTD. (JP) 1991-08-13 US disclosed
EP-0405808-A1 Phenoxyalkylamine derivatives and insecticides, acaricides and fungicides UBE INDUSTRIES, LTD. (JP) 1991-01-02 EP disclosed