Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridoxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.45 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | PDXK | O00764 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridoxamine SCHEMBL30017752 | 0.85 | LMNA (0.79) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL30408 | 0.83 | LMNA (1.00) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29388349 | 0.82 | LMNA (0.65) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL7749395 | 0.82 | LMNA (0.96) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL561421 | 0.82 | LMNA (0.96) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL48103 | 0.82 | LMNA (0.96) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL29391467 | 0.81 | LMNA (0.63) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL638186 | 0.81 | LMNA (0.71) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxine SCHEMBL23647341 | 0.80 | KDM4E (0.83) | LMNAKDM4EALDH1A1HPGDHSD17B10 | |
| Pyridoxamine SCHEMBL4876978 | 0.80 | LMNA (0.93) | LMNAKDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5463030-A | Complexes of diethylenetriaminepentaacetic acid derivatives with paramagnetic lanthanide series metals; magnetic resonance imaging contrast agents | RESEARCH FOUNDATION OF THE STATE OF NEW YORK (US) | 1995-10-31 | — | — | US | disclosed |