Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 10/20 | 0.36 |
| ▸ | HTR2C | P28335 | 4/20 | 0.36 |
| ▸ | HTR2B | P41595 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9148120 | 0.98 | ADRA2A (0.36) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL22322460 | 0.70 | HTR2C (0.44) | HTR2C | |
| SCHEMBL9151565 | 0.69 | CHRM2 (0.38) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9148850 | 0.69 | HTR2A (0.41) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9149638 | 0.69 | HTR2A (0.38) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9519154 | 0.69 | CHRM2 (0.40) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9155409 | 0.69 | HTR2A (0.40) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9148160 | 0.68 | HTR2A (0.37) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9152691 | 0.67 | HTR2A (0.36) | ADRA2AADRA2BHTR2AHTR2CHTR2B | |
| SCHEMBL9152149 | 0.66 | CHRM2 (0.46) | ADRA2AADRA2BHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |