Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 8/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15001490 | 0.73 | HRH3 (0.42) | HTR2AHTR2C | |
| SCHEMBL9149638 | 0.70 | HTR2A (0.38) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL9151997 | 0.69 | ADRA2A (0.37) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| Hydrochloric Acid SCHEMBL9772133 | 0.69 | CHRM2 (0.36) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL8400415 | 0.69 | CHRM1 (0.48) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9148160 | 0.69 | HTR2A (0.37) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL10002194 | 0.69 | NOS1 (0.55) | NOS1 | |
| Hydrochloric Acid SCHEMBL9148120 | 0.68 | ADRA2A (0.36) | CHRM2CHRM3HTR2AHTR2CHTR2B | |
| SCHEMBL14510156 | 0.68 | NOS1 (0.34) | NOS1 | |
| SCHEMBL9154724 | 0.67 | HTR2A (0.35) | CHRM2CHRM3HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0296721-B1 | HETEROCYCLIC COMPOUNDS | H. LUNDBECK A/S (DK) | 1993-06-23 | — | — | EP | disclosed |
| US-4925858-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1990-05-15 | — | — | US | disclosed |
| US-4866077-A | TREATMENT OF NERVOUS SYSTEM DISORDERS SUCH AS ALZHEIMER*S DISEASE | H. LUNDBECK A/S (DK) | 1989-09-12 | — | — | US | disclosed |
| EP-0296721-A2 | Heterocyclic compounds | H. LUNDBECK A/S (DK) | 1988-12-28 | — | — | EP | disclosed |