Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4032070 | 0.87 | RORC (0.57) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL541264 | 0.84 | MAPT (0.59) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL21676105 | 0.81 | TAAR1 (0.56) | KDM4EKMT2AMAPK10RIPK1 | |
| SCHEMBL25183518 | 0.81 | MAPK10 (0.47) | KDM4EMEN1KMT2AMAPK10RIPK1 | |
| SCHEMBL10099057 | 0.78 | MAPT (0.57) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL9148539 | 0.77 | AR (0.43) | MAPTMAPK10RIPK1AR | |
| SCHEMBL20780028 | 0.77 | MAPT (0.56) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL11753126 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL5458644 | 0.75 | KDM4E (0.57) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL395329 | 0.75 | MAPT (0.54) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5451600-A | FOR TREATMENT OF INFLAMMATORY DISEASES AND TRAUMA INDUCED INFLAMMATION | HOFFMANN-LA ROCHE INC. (US) | 1995-09-19 | — | — | US | disclosed |