SCHEMBL9153971

SCHEMBL9153971

O=C(Br)CCCC[PH](c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
ALPL P05186 1/20 0.39
ALPI P09923 1/20 0.39
ALPG P10696 1/20 0.39
L3MBTL1 Q9Y468 2/20 0.38
MAPT P10636 2/20 0.38
LMNA P02545 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
POLB P06746 1/20 0.38
BLM P54132 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
HDAC1 Q13547 9/20 0.36
HDAC8 Q9BY41 8/20 0.35
HDAC4 P56524 4/20 0.35
HDAC7 Q8WUI4 4/20 0.35
HDAC2 Q92769 4/20 0.35
HDAC11 Q96DB2 4/20 0.35
HDAC6 Q9UBN7 4/20 0.35
HDAC9 Q9UKV0 4/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7231474 0.86 ALDH1A1 (0.34) MEN1KMT2AL3MBTL1MAPTLMNA
SCHEMBL1838985 0.85 HDAC3 (0.50) L3MBTL1MAPTLMNATDP1HDAC1
SCHEMBL7620280 0.83 HDAC3 (0.53) MEN1KMT2AL3MBTL1MAPTLMNA
Bicarbonate SCHEMBL8972417 0.83 HDAC3 (0.48) MEN1KMT2AALPLALPIALPG
SCHEMBL7624634 0.83 HDAC3 (0.53) MEN1KMT2AL3MBTL1MAPTLMNA
Hydrochloric Acid SCHEMBL11060629 0.83 HDAC3 (0.48) L3MBTL1MAPTLMNAHDAC1HDAC8
SCHEMBL10845864 0.83 HDAC3 (0.48) MEN1KMT2AALPLALPIALPG
SCHEMBL2963290 0.83 HDAC3 (0.53) MEN1KMT2AL3MBTL1MAPTLMNA
SCHEMBL20859564 0.83 HDAC3 (0.53) MEN1KMT2AL3MBTL1MAPTLMNA
SCHEMBL11569319 0.83 TBXAS1 (0.40) MEN1KMT2AALPLALPIALPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5445724-A Phosphonium salts and use thereof as brighteners for aqueous acidic electronickelization baths BASF AKTIENGESELLSCHAFT (DE) 1995-08-29 US disclosed
US-5436343-A Thromboxane A2 receptor antagonist, thromoboxane A2 synthase inhibitor ADIR ET COMPAGNIE (FR) 1995-07-25 US disclosed
EP-0144459-A1 Prostaglandins, their preparation and pharmaceutical compositions Dr. Willmar Schwabe GmbH & Co. (DE) 1985-06-19 EP disclosed
US-4309351-A INTERMEDIATES FOR PROSTAGLANDIN-LIKE COMPOUNDS THE UNIVERSITY OF CHICAGO (US) 1982-01-05 US disclosed
US-4071530-A Pyrrolidones and process for preparing them HOECHST AKTIENGESELLSCHAFT (DT) 1978-01-31 US disclosed
US-4025546-A Prostaglandin analogues AKZO N.V. (NL) 1977-05-24 US disclosed
US-3971825-A (5,6) (10,11) BIS-METHYLENE, BRONCHODILATORS SANKYO COMPANY LIMITED (JA) 1976-07-27 US disclosed
US-3953470-A Substituted prostaglandin derivatives SYNTEX (U.S.A.) INC. (US) 1976-04-27 US disclosed
US-3931297-A 10-Hydroxy PGC compounds SYNTEX (U.S.A.) INC. (US) 1976-01-06 US disclosed