Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9154527 | 1.00 | TRPV3 (0.33) | TRPV3OPRL1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL9154514 | 1.00 | TRPV3 (0.33) | TRPV3OPRL1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL9154511 | 1.00 | TRPV3 (0.33) | TRPV3OPRL1ALDH1A1SLC6A2SLC6A4 | |
| SCHEMBL9157398 | 0.90 | OPRL1 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL9157383 | 0.90 | OPRL1 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL9157375 | 0.90 | OPRL1 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL9157391 | 0.90 | OPRL1 (0.36) | OPRL1ALDH1A1 | |
| SCHEMBL9156448 | 0.87 | GAA (0.37) | OPRL1 | |
| SCHEMBL9156440 | 0.87 | GAA (0.37) | OPRL1 | |
| SCHEMBL9156444 | 0.87 | GAA (0.37) | OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5205962-A | Stable liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| EP-0445248-A1 | PYRIDINE DERIVATIVES. | MERCK PATENT GMBH (DE) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |