Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.42 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2123138 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL6892150 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL9311863 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL3131682 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL6894372 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL9173529 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL1134616 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL10361962 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL2812471 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL27992053 | 1.00 | MEN1 (0.49) | MEN1KMT2AMAPK1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4252826-A | CARBOXYLATE OF A METHYL POLYETHOXYLATED GLUCOSIDE AND A PRESERVATIVE AGENT | L'OREAL (FR) | 1981-02-24 | — | — | US | claimed |
| US-4196201-A | Non-irritating eye make-up remover composition | L'OREAL (FR) | 1980-04-01 | — | — | US | claimed |
| EP-0356210-B1 | Method of enhancing fabric rewettability | DOW CORNING (US) | 1995-09-13 | — | — | EP | disclosed |
| EP-0415540-B1 | Antimicrobial rinse cycle additive | DOW CORNING (US) | 1995-06-14 | — | — | EP | disclosed |
| EP-0363080-B1 | Softening composition | DOW CORNING (US) | 1995-01-11 | — | — | EP | disclosed |
| US-5145596-A | Quaternary ammonium silane compound | DOW CORNING CORPORATION (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0415540-A1 | Antimicrobial rinse cycle additive | DOW CORNING CORPORATION (US) | 1991-03-06 | — | — | EP | disclosed |
| CN-1010957-B | Novel acid-dyeing agent | FUKANG AUXILIARY AGENTS PLANT (CN) | 1990-12-26 | — | — | CN | disclosed |
| EP-0363080-A1 | Softening composition | DOW CORNING CORPORATION (US) | 1990-04-11 | — | — | EP | disclosed |
| US-4908140-A | Rinse cycle fabric softener conditioner capable of producing hydrophobic surface on fabrics comprising polysiloxane and quaternary ammonium salts and C12 to C18 hydrocarbon chain esters, amines, acids, or amine oxides | DOW CORNING CORPORATION (US) | 1990-03-13 | — | — | US | disclosed |
| EP-0356210-A2 | Method of enhancing fabric rewettability | DOW CORNING CORPORATION (US) | 1990-02-28 | — | — | EP | disclosed |
| US-4846982-A | ORGANIC SURFACTANTS, BUILDERS | DOW CORNING CORPORATION (US) | 1989-07-11 | — | — | US | disclosed |
| US-4323468-A | NONIONIC SURFACTANTS AND EXTRACT OF SARSAPARILLA | L'OREAL (FR) | 1982-04-06 | — | — | US | disclosed |
| US-4196201-A | Non-irritating eye make-up remover composition | L'OREAL (FR) | 1980-04-01 | — | — | US | disclosed |