Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 1.00 |
| ▸ | RAB9A | P51151 | 12/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.65 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | GAA | P10253 | 5/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12910353 | 0.90 | NPC1 (0.81) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL12910367 | 0.85 | NPC1 (0.73) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1675417 | 0.84 | NPC1 (0.73) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2249527 | 0.83 | RAB9A (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL17391943 | 0.83 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9868181 | 0.83 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL941615 | 0.83 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4143617 | 0.83 | NPC1 (0.71) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL31631307 | 0.83 | NPC1 (1.00) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL21249244 | 0.83 | NPC1 (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9695193-B2 | Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-07-04 | — | — | US | disclosed |
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | UNIV COLUMBIA (US) | 2016-05-05 | — | — | US | disclosed |
| EP-0284567-B1 | Cationic azo dyes | CIBA GEIGY AG (CH) | 1995-03-01 | — | — | EP | disclosed |
| US-4880916-A | COLORFAST; FOR PAPER, TEXTILES, LEATHER | CIBA-GEIGY CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |
| US-4880916-A | COLORFAST; FOR PAPER, TEXTILES, LEATHER | CIBA-GEIGY CORPORATION (US) | 1989-11-14 | — | — | US | disclosed |
| EP-0284567-A2 | Cationic azo dyes | CIBA-GEIGY AG (CH) | 1988-09-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160122362-A1 | INHIBITORS OF PLASMODIUM FALCIPARUM EQUILIBRATIVE NUCLEOSIDE TRANSPORTER TYPE I AS ANTI-PARASITIC COMPOUNDS | SLC29A1, SLC29A2, SLC28A1 | NPC1 144/4885RAB9A 1709/4885ALDH1A1 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.