Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155864 | 1.00 | TDP1 (0.45) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL9155872 | 1.00 | TDP1 (0.45) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10512678 | 0.84 | HSP90AA1 (0.42) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10512684 | 0.84 | HSP90AA1 (0.42) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10512674 | 0.84 | HSP90AA1 (0.42) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10510528 | 0.79 | MAPT (0.39) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10510518 | 0.79 | MAPT (0.39) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL10510513 | 0.79 | MAPT (0.39) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL9155805 | 0.75 | TSHR (0.40) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 | |
| SCHEMBL9195034 | 0.75 | ABCC9 (0.44) | TDP1ALDH1A1CYP3A4TSHRHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401848-A | Indane and quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 1995-03-28 | — | — | US | disclosed |
| CN-1061961-A | 1,2-indane and quinoline | SQUIBB & SONS INC (US) | 1992-06-17 | — | — | CN | disclosed |
| EP-0488616-A1 | Indane and quinoline derivatives | E.R. SQUIBB & SONS, INC. (US) | 1992-06-03 | — | — | EP | disclosed |