Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14765559 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL3947212 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL3942504 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL13460693 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL7768140 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL3942509 | 0.76 | ABCC9 (0.39) | TSHRLMNAALDH1A1TDP1ACHE | |
| SCHEMBL9155872 | 0.75 | TDP1 (0.45) | TSHRALDH1A1TDP1CHRNB4CHRNA3 | |
| SCHEMBL9155864 | 0.75 | TDP1 (0.45) | TSHRALDH1A1TDP1CHRNB4CHRNA3 | |
| SCHEMBL9155877 | 0.75 | TDP1 (0.45) | TSHRALDH1A1TDP1CHRNB4CHRNA3 | |
| SCHEMBL10512678 | 0.74 | HSP90AA1 (0.42) | TSHRLMNAALDH1A1TDP1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401848-A | Indane and quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0488616-A1 | Indane and quinoline derivatives | E.R. SQUIBB & SONS, INC. (US) | 1992-06-03 | — | — | EP | disclosed |
| EP-0321175-A1 | Indane derivatives | BEECHAM GROUP PLC (GB) | 1989-06-21 | — | — | EP | disclosed |